Sox2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas

HIGHLIGHTS

  • who: Carcinomas and colleagues from the La TroncheEditor: Alexander Idnurm, University of Missouri Kansas City, United States of America have published the Article: SOX2 Is an Oncogene Activated by Recurrent 3q26.3 Amplifications in Human Lung Squamous Cell Carcinomas, in the Journal: (JOURNAL) of January/29,/2010
  • what: The authors show that SOX2 has a major impact on global lung SCC transcriptome deregulation and contributes to activate ESClike transcriptome phenotypes, thereby establishing SOX2 as a key up-regulated transcription factor in lung SCC which modulates both direct and indirect key target genes involved in tumor . . .

     

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