Sox4 and rela function as transcriptional partners to regulate the expression of tnf- responsive genes in fibroblast-like synoviocytes

HIGHLIGHTS

  • who: Kyle Jones and colleagues from the Department of Orthopaedics, Emory University School of Medicine, Atlanta, GA, United States, Department of Cell have published the Article: SOX4 and RELA Function as Transcriptional Partners to Regulate the Expression of TNF- Responsive Genes in Fibroblast-Like Synoviocytes, in the Journal: (JOURNAL)
  • what: The aim of this study is to understand the mechanisms underlying the interaction between TNF and its major transcriptional mediator, RELA/p65 with the SOXC family transcription factors and to determine if SOXC proteins act as transcriptional partners of RELA to promote TNFinduced pathological behavior . . .

     

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