Sox9 and tcf transcription factors associate to mediate wnt/β-catenin target gene activation in colorectal cancer

HIGHLIGHTS

• who: Aravinda-Bharathi Ramakrishnan from the Aravinda-Bharathi Ramakrishnan, Peter EBurby, Kavya Adiga, and Ken M. Cadigan* From the Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA Edited by Brian Strahl have published the research work: SOX9 and TCF transcription factors associate to mediate Wnt/u03b2-catenin target gene activation in colorectal cancer, in the Journal: (JOURNAL)
• what: The work demonstrates a highly context-dependent effect of SOX9 on Wnt targets, with the presence or absence of SOX9-binding_sites on Wnt-regulated enhancers determining whether they are directly activated . . .
  

   

  

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