HIGHLIGHTS
- who: Katarina Bacevic from the University of have published the Article: Spatial competition constrains resistance to targeted cancer therapy, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: The authors focused on cyclin-dependent kinases (CDKs), which control the cell cycle and whose pathways are universally deregulated in cancer9. From these considerations and a geometrical analysis of resistant subclone growth within a threedimensional tumour (Supplementary Methods; Supplementary Fig 1), the authors propose that the relationship between the relative fitness and the frequency of resistant cells can be more realistically represented by a sigmoidal function, with its . . .
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