HIGHLIGHTS
- who: Saara Hämälistö from the Recycling and Disease, Danish Cancer Society Research Center, Copenhagen, DenmarkStellenbosch University have published the paper: Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: Taking advantage of a highly sensitive galectin puncta assay to visualize leaky lysosomes, the authors show here, that a minor, non-lethal permeabilization of lysosomal membrane occurs frequently in cultured human cells and healthy murine tissues in prometaphase. The authors provide data indicating that CTSB leaking out of prometaphase lysosomes and acting on (pro)metaphase . . .
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