Spatially clustered loci with multiple enhancers are frequent targets of hiv-1 integration

HIGHLIGHTS

• who: Bojana Lucic from the Heidelberg University Infection Research, Heidelberg, Germany have published the paper: Spatially clustered loci with multiple enhancers are frequent targets of HIV-1 integration, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors show that HIV-1 recurrently integrates into a group of genes proximal to SE genomic elements in activated CD4+ T_cells and in patients (Fig 1c). 3D compartmentalization plays a role only in the second process, explaining why studies with different definitions of HIV-1 targets may come to different conclusions. | https://doi.org/10.1038/s41467-019 . . .
  

   

  

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