HIGHLIGHTS
SUMMARY
Follicular-patterned thyroid nodules are common and include a broad range of lesions, from benign (hyperplastic nodules, adenomatoid nodules, follicular adenomas (FA)) to malignant neoplasms (follicular carcinoma (FC), follicular variant of papillary thyroid carcinoma (FVPTC)). Genomics and proteomics are promising approaches to investigate the thyroid cancer landscape and to provide its molecular snapshots, whilst benign as well as NIFTPs are still poorly investigated. The majority of NIFTPs are characterised by the presence of RAS mutations, although this molecular signature is not always present, rendering the diagnosis of RAS wild-type lesions challenging, especially in . . .
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