HIGHLIGHTS
- who: Ceniz Zihni and colleagues from the Rockefeller University Press JCell Biol. , Vol. , No. , e, have published the Article: Spatiotemporal control of actomyosin contractility by MRCK signaling drives phagocytosis, in the Journal: (JOURNAL) of 25/02/2023
- what: The authors show that in the retinal pigment epithelium (RPE), particle binding to Mer Tyrosine Kinase (MerTK), a widely expressed phagocytic receptor, stimulates phosphorylation of the Cdc42 GEF Dbl3, triggering activation of MRCKu03b2/myosin-II and its coeffector N-WASP, membrane deformation, and cup formation.
SUMMARY
Deregulation of MerTK-regulated phagocytosis has been . . .
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.