Spatiotemporal control of necroptotic cell death and plasma membrane recruitment using engineered mlkl domains

HIGHLIGHTS

• who: Amir Taslimi from the (UNIVERSITY) have published the research: Spatiotemporal control of necroptotic cell death and plasma membrane recruitment using engineered MLKL domains, in the Journal: (JOURNAL) of 29/07/2022
• what: The studies showed increased membrane blebbing upon necroptosis activation with several identified hits (Supplementary Fig S5). Using SsrA-MLKL, the authors demonstrate robust, reversible PM recruitment, which the authors applied to regulate inositol phosphatase activity. The work demonstrates the functionality of a new optogenetic tool, FLAG-MLKL, that has a number of advantages over chemical approaches, such as the ability to steer . . .
  

   

  

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