HIGHLIGHTS
- who: Richard A. Stein and Hassane S. Mchaourab from the Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, United have published the research work: SPEACH_AF: Sampling protein ensembles and conformational heterogeneity with Alphafold2, in the Journal: (JOURNAL) of August/22,/2022
- what: The authors develop a general approach to transcend this apparent limitation of AF2 and consequently predict ensembles of conformations. The analysis of these two canonical examples of conformational flexibility indicate that the molprobity scores can be used as a first screen for misfolded models in the absence of any prior structures . . .
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