Special article – methods the clinical meaning of the area under receiver operating characteristic curve for the evaluation of the performance of disease markers

HIGHLIGHTS

SUMMARY

Receiver Operating Characteristic (ROC) curves are standard statistical tools for the analysis of disease markers (DM). In many instances the partial area pAUC is preferred to AUC. pAUC can be computed ub in a range of allegedly meaningful either specificity or sensitivity values. Such a comparison may be prone to an insufficient statistical power, the results of the test can strongly depend on the selected range of specificity, and the estimation of pAUC is likely to be more noticeably affected than AUC by the shape of the fitted ROC curve. An interesting property of . . .

 



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