HIGHLIGHTS
- who: Eszter Banki from the Institute of Anatomy, University of Zurich, Zurich, Switzerland have published the Article: Specific disruption of calcineurin-signaling in the distal convoluted tubule impacts the transcriptome and proteome, and causes hypomagnesemia and metabolic acidosis, in the Journal: (JOURNAL) of 31/07/2020
SUMMARY
Translational Statement Calcineurin inhibitors (CNIs), such as tacrolimus and cyclosporine A, have several adverse effects, including arterial hypertension, hyperkalemia, and hypomagnesemia. This study employed a conditional knockout mouse model to define the specific role of disrupted calcineurin signaling in the renal distal convoluted tubule. The regulatory . . .
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