Specific inhibition of phorbol ester-stimulated phospholipase d by clostridium sordellii lethal toxin and clostridium difficile toxin b-1470 in hek-293 cells

HIGHLIGHTS

• who: Martina Schmidt from the lated PLD activity in , cells seems to be largely independent of the GTP/GDP binding state of Ral proteins but may not involve active RasFirst, full restoration of PMA-stimulated PLD activity in membranes of , cells treated with TcsL or Tcd, by Ral proteins was observed without adding GTP or GTPgS. Second, PLD stimulation by PMA and GTPgS in , cells was simply additive (42), and the latter one was not affected by inactivation of Ras-like GTPases. Third, the addition of recombinant RasG V, a constitutively active Ras mutant, to membranes of . . .
  

   

  

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