Specific irreversible cell-cycle arrest and depletion of cancer cells obtained by combining curcumin and the flavonoids quercetin and fisetin

HIGHLIGHTS

  • who: Viviana Barra and collaborators from the Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo have published the article: Specific Irreversible Cell-Cycle Arrest and Depletion of Cancer Cells Obtained by Combining Curcumin and the Flavonoids Quercetin and Fisetin, in the Journal: Genes 2022, 13, 1125. of /2022/
  • what: The authors report that curcumin treatment specifically triggers senescence in cancer cells by inducing mitotic slippage and damage. The authors show that curcumin-induced senescence is p21waf1/cip1 -dependent and characterized by heterochromatin loss. The authors investigate the mechanism/s underlying curcumin . . .

     

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