Specific mutations in the cholesterol-binding site of app alter its processing and favor the production of shorter, less toxic aβ peptides

HIGHLIGHTS

• who: Linda Hanbouch from the Paris Brain Institute, ICM, CNRS UMR7225-INSERM University Hu00f4pital de La Pitiu00e9-Salpu00eatriu00e8re, Bd de lu2019Hu00f4pital, Paris, France have published the research work: Specific Mutations in the Cholesterol-Binding Site of APP Alter Its Processing and Favor the Production of Shorter, Less Toxic Au03b2 Peptides, in the Journal: (JOURNAL)
• what: The authors show that most mutations triggered a reduction of Au03b240 and Au03b242 secretion from transiently transfected HEK293T_cells. The authors demonstrate that mutations in the transmembrane or in the juxtamembrane regions of APP involved in cholesterol-binding differentially regulate APP . . .
  

   

  

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