Spectrofluorimetric and computational investigation of new phthalimide derivatives towards human neutrophil elastase inhibition and antiproliferative activity

HIGHLIGHTS

  • who: Beata Donarska and colleagues from the Department of Chemical Technology and Pharmaceuticals, Faculty of Pharmacy, Collegium Medicum, Nicolaus Copernicus University, Jurasza, Bydgoszcz, Poland have published the research work: Spectrofluorimetric and Computational Investigation of New Phthalimide Derivatives towards Human Neutrophil Elastase Inhibition and Antiproliferative Activity, in the Journal: (JOURNAL)
  • what: The authors report the synthesis of new phthalimide-thiazole derivatives and investigate them as new human neutrophil elastase (HNE) inhibitors using spectrofluorimetric and computational methods.
  • how: The main compounds were tested for their antitumor activity against four human cancer cells lines namely biphenotypic . . .

     

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