Sperm dna fragmentation and sperm-borne mirnas: molecular biomarkers of embryo development?

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SUMMARY

    What is a "healthy" spermatozoon? The most abundant miRNA in the male gamete, miR-34c, has been described as essential for the first cell division in mouse zygotes and has been correlated with the success of Intracytoplasmic Sperm Injection (ICSI). MiR-34c is often associated with miR-449b, part of the miR-449a/b/c family. In light of this, SDF, sperm miR-34c and miR-449b would appear to have a promising role as biomarkers of seminal quality and ART outcome. The aim of this study was to analyze SDF and sperm miR . . .

     

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