Sphingosine 1-phosphate activation of egfr as a novel target for meningitic escherichia coli penetration of the blood-brain barrier

HIGHLIGHTS

• who: Xiangru Wang and colleagues from the Department of Pediatrics, Division of Pediatric Infectious Diseases, Johns Hopkins University School of have published the research: Sphingosine 1-Phosphate Activation of EGFR As a Novel Target for Meningitic Escherichia coli Penetration of the Blood-Brain Barrier, in the Journal: (JOURNAL)
• what: The work demonstrated for the first time that sphingosine 1-phosphate (S1P) activation of epidermal growth factor receptor (EGFR) represents a novel mechanism by which CNS-infecting E. coli strains penetrate the BBB and that blockade of S1P and EGFR prevented E. coli penetration of the . . .
  

   

  

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