HIGHLIGHTS
- who: Tuoyu Geng from the DepartmentsMedical University have published the Article: SphK1 mediates hepatic inflammation in a mouse model of NASH induced by high saturated fat feeding and initiates proinflammatory signaling in hepatocytes, in the Journal: (JOURNAL)
- what: The aim of this study was to test whether SphK1 increases in NAFLD, whether it plays a proinflammatory role, and, if so, to determine the mechanism. The authors demonstrated that high saturated fat feeding in mice recapitulated defining features of NASH, presenting a novel and potentially broadly useful model of this disease. As these are key components . . .
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