Spinal cord dorsal horn sensory gate in preclinical models of chemotherapy-induced painful neuropathy and contact dermatitis chronic itch becomes less leaky with kcc2 gene expression-enhancing treatments

HIGHLIGHTS

• who: Yong Chen and Wolfgang Liedtke from the University of the Ryukyus, Japan have published the research work: Spinal cord dorsal horn sensory gate in preclinical models of chemotherapy-induced painful neuropathy and contact dermatitis chronic itch becomes less leaky with Kcc2 gene expression-enhancing treatments, in the Journal: (JOURNAL)
• how: Of several advantageous compounds that the authors identified in the screening and subsequent work-up kenpaullone was selected for in-depth characterization. The authors implemented effective peripheral analgesia in a Taxol-CIPN preclinical model. The authors implemented a mouse preclinical model of CIPN by . . .
  

   

  

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