HIGHLIGHTS
- who: Jean-Baptiste Reisqs and collaborators from the Neuromyogene Institute, Claude Bernard University, Lyon, Villeurbanne, France have published the paper: Spironolactone as a Potential New Treatment to Prevent Arrhythmias in Arrhythmogenic Cardiomyopathy Cell Model, in the Journal: (JOURNAL)
- what: The authors assess the direct effect of SP and its metabolite canrenoic acid (CA) in cardiomyocytes derived from human-induced pluripotent stem cells (hiPSC-CMs) of a patient bearing a missense mutation (c.394C>T) in the DSC2 gene coding for desmocollin 2 and for the amino acid replacement of arginine by cysteine at position 132 . . .
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