Spironolactone for adult female acne (safa): protocol for a double- blind, placebo- controlled, phase iii randomised study of spironolactone as systemic therapy for acne in adult women

HIGHLIGHTS

• who: Susanne Renz ‍ ‍ and colleagues from the This is the first adequately powered pragmatic, randomised trial investigating the effect of spironolactone on acne in adult women in comparison to a matched placeboIf found to be clinically effective and cost effective, use of spironolactone will likely become the new standard of care in addition to topical treatments potentially reducing antibiotic use for women requiring systemic therapy. Respondents to a survey of people with experience with acne reported that they would be unwilling to be recruited to a study where they remained blinded to the treatment allocation for , weeks . . .
  

   

  

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