Spontaneous and ligand-induced trafficking of cxc-chemokine receptor 4*

HIGHLIGHTS

• who: Nadya I. Tarasova from the (UNIVERSITY) have published the paper: Spontaneous and Ligand-induced Trafficking of CXC-Chemokine Receptor 4*, in the Journal: (JOURNAL)
• what: This study provides evidence that the viral envelope glycoprotein gp120 is a high affinity ligand of CXCR4 and that SDF-1a and gp120 induce endocytosis of CXCR4 that is significantly irreversible. The authors demonstrate that recycling of CXCR4 is not efficient, and, unlike CCKAR, a significant portion of CXCR4 molecules could be detected in lysosomes after addition of the ligand.
• how: The following reagents were obtained through . . .
  

   

  

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