HIGHLIGHTS
SUMMARY
Subsequently, Ca2+ binds to SV-associated Ca2+ sensors of the synaptotagmin family and induces SV fusion (Littleton and Bellen, 1995; Kochubey et_al, 2011; Südhof, 2012a) which depends on the formation of the neuronal SNARE complex consisting of vesicular VAMP2/synaptobrevin and the plasma_membrane proteins SNAP-25 and syntaxin-1 (Südhof and Rothman, 2009; Jahn and Fasshauer, 2012; Rizo, 2018). AP-evoked NT release further requires the SNARE-binding proteins (M)Unc13 and_(M)Unc18 (Brose et_al, 2000; Richmond and Broadie, 2002; Toonen and Verhage, 2007; Dittman, 2019). Live imaging experiments furthermore revealed . . .
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