Sputum microbe community alterations induced by long-term inhaled corticosteroid use are associated with airway function in chronic obstructive pulmonary disease patients based on metagenomic next-generation sequencing (mngs)

HIGHLIGHTS

• What: Considering an alpha of 0.05 and a power of 80%, the sample size of the study was 30 for each group (the calculated size was 28). Similar to the results reported by a previous study by Contoli et_al involving 12 months` of ICS/LABA treatment (Contoli et_al, 2017), this study showed that the long-term use of ICS as part of triple therapy had the tendency to increase the alpha diversity of the microbiota at the genus level. ICS has been shown to coincide with beta diversity (Pragman et_al, 2012), and this study showed a . . .
  

   

  

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