HIGHLIGHTS
- who: Shaoyi Zhang from the (UNIVERSITY) have published the article: Squaramide-based synthetic chloride transporters activate TFEB but block autophagic flux, in the Journal: (JOURNAL)
- what: The authors report that such chloride anionophores block autophagic flux in spite of the fact that they activate the pro-autophagic transcription factor EB (TFEB) coupled to the inhibition of the autophagy-suppressive mTORC1 kinase activity.
- how: Data were analyzed using Prism (GraphPad Software Inc [].
SUMMARY
Cystic fibrosis is the most frequent monogenetic lethal disease affecting humans1,2. SQ1 and SQ2 incorporate into . . .
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