HIGHLIGHTS
- who: Abdallah A. Omar from the National Cancer Institute have published the paper: St. Jude Total Therapy studies from I to XVII for childhood acute lymphoblastic leukemia: a brief review, in the Journal: (JOURNAL)
- what: Total Therapies I and II had the main aim of rapidly achieving complete remission, evading resistance, complete eradication of residual leukemic cells from which resistant cells arose by introducing the idea of the combination of multiple effective therapeutic agents with a different mechanism of actions, full dose rather than half dose, and prevention of CNS leukemia through prophylactic irradiation therapy . . .
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