Stable expression of a truncated tlx variant drives differentiation of induced pluripotent stem cells into self-renewing neural stem cells for production of extracellular vesicles

HIGHLIGHTS

  • who: Mingzhi Xu from the State Key Laboratory of Proteomics, National Center for Protein of Lifeomics, Beijing, China have published the research work: Stable expression of a truncated TLX variant drives differentiation of induced pluripotent stem cells into self-renewing neural stem cells for production of extracellular vesicles, in the Journal: (JOURNAL)
  • what: We developed an iPSC-derived NSC line that allowed the long-term passaging and production of extracellular vesicles with anti-neuroinflammatory activities.
  • how: The results showed that the stable expression of a truncated version of TLX allowed self-driven differentiation . . .

     

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