Stat3 suppression and β-cell ablation enhance α-to-β reprogramming mediated by pdx1

HIGHLIGHTS

• who: Yuka Wakabayashi from the DepartmentKitasato University have published the paper: STAT3 suppression and u03b2-cell ablation enhance u03b1-to-u03b2 reprogramming mediated by Pdx1, in the Journal: Scientific Reports Scientific Reports
• how: As the studies by Matsuoka et_al and Cigliola et_al both used the CAG-CAT-Pdx1FLAG mice that the authors previously u00adgenerated26 the expression levels of PDX1 in the mice are expected to be the same after Cre-mediated recombination in the study and these previous studies. One of the obvious differences is that tamoxifen-inducible Gcg-CreER mice were used to induce . . .
  

   

  

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