HIGHLIGHTS
- who: Maya A. Lewinsohn from the Centre , have published the research: State-dependent evolutionary models reveal modes of solid tumour growth, in the Journal: (JOURNAL) of 26/01/2023
- what: The authors demonstrate that faster division on the tumour periphery leaves characteristic genetic patterns, which become evident when a phylogenetic tree is reconstructed from spatially sampled cells. The authors develop a Bayesian state-dependent evolutionary phylodynamic model (SDevo) that quantifies these patterns to infer the differential division rates between peripheral and central cells. The authors demonstrate that this approach accurately infers spatially varying birth rates . . .
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