Stereoselective block of the herg potassium channel by the class ia antiarrhythmic drug disopyramide

HIGHLIGHTS

• What: This study evaluated effects of enantiomers on current ­(IhERG) from expressing HEK 293 cells at 37 °C. S(+) and R(-) inhibited wild-type (WT) I­ with ­IC50 values of 3.9 µM and 12.9 µM respectively.
• Who: Yihong Zhang from the School of Physiology, Pharmacology and Neuroscience, Biomedical Sciences Building, University of Bristol, University Walk, Bristol , TD, UK have published the research work: Stereoselective block of the hERG potassium channel by the Class Ia antiarrhythmic drug disopyramide, in the Journal: (JOURNAL)
• How: Electrophysiology data_analysis Data were analyzed using Clampfit 10.2 . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or Email

  Password

  Remember me

  Lost your password?

  If you don't have an account, you can create one here.