Steric accessibility of the n-terminus improves the titer and quality of recombinant proteins secreted from komagataella phaffii

HIGHLIGHTS

• who: Neil C. Dalvie from the Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA have published the research: Steric accessibility of the N-terminus improves the titer and quality of recombinant proteins secreted from Komagataella phaffii, in the Journal: (JOURNAL)
• what: The authors determined that an aggregated productrelated variant of several recombinant proteins secreted from K. phaffii was caused by incomplete cleavage of the secretion signal peptide.
• how: The authors evaluated the impact of signal peptide processing on the quality and secreted titer of several recombinant therapeutic proteins and tested . . .
  

   

  

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