HIGHLIGHTS
- who: Flora Magnotti from the CNRS University Lyon, Lyon, France have published the research work: Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism, in the Journal: (JOURNAL) of October/11,/2022
- how: To evaluate the stereospecificity of the response the two stereoisomers of etiocholanolone were tested for their ability to trigger p.S242R-MEFV-dependent cell death. The authors then decided to investigate the effects of steroid catabolites on cells from PAAND patients in which the pyrin inflammasome step1 is constitutively activated leading to a pyrin inflammasome controlled mostly at step . . .
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