HIGHLIGHTS
- who: Magdalena Marek et al. from the (UNIVERSITY) have published the paper: Sterol biosensor reveals LAM-family Ltc1-dependent sterol flow to endosomes upon Arp2/3 inhibition, in the Journal: (JOURNAL) of 02/09/2022
- what: The authors show that sterols undergo retrograde trafficking from the PM to endosomes, in a manner strictly dependent on a single, previously uncharacterized StARkinprotein Ltc1, and return to the PM by means independent of vesicular trafficking. The authors focused on cells that contained internal and PM signal, with the latter used to align the light and EM images. Below . . .
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