HIGHLIGHTS
- who: Suzanne A.E. van Wouw from the Department of Medical Biochemistry, UMC, Institutes of and Metabolism, of, AZ, the Utrecht, the have published the article: Sterol-regulated transmembrane protein TMEM86a couples LXR signaling to regulation of lysoplasmalogens in macrophages, in the Journal: (JOURNAL)
- what: The authors demonstrate that TMEM86a is direct transcriptional target of macrophages and microglia and that it is highly expressed TREM2+/lipid-associated macrophages human atherosclerotic plaques where its expression positively correlates with other genes. The authors demonstrate that overexpression of Tmem86a BMDM markedly reduces lysoplasmalogen abundance and membrane fluidity while . . .
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