Sterol-regulated transmembrane protein tmem86a couples lxr signaling to regulation of lysoplasmalogens in macrophages

HIGHLIGHTS

• who: Suzanne A.E. van Wouw from the Department of Medical Biochemistry, Amsterdam UMC, Amsterdam Institutes of Cardiovascular Sciences, Infection and Immunity, and Gastroenterology Endocrinology and Metabolism, University of Amsterdam, Amsterdam, the Netherlands have published the research work: Sterol-regulated transmembrane protein TMEM86a couples LXR signaling to regulation of lysoplasmalogens in macrophages, in the Journal: (JOURNAL)
• what: The authors demonstrate that TMEM86a is direct transcriptional target of LXR in macrophages and microglia and that it is highly expressed in TREM2-/ lipid-associated macrophages in human atherosclerotic plaques where its expression positively correlates with other genes . . .
  

   

  

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