Stf-62247 and pimozide induce autophagy and autophagic cell death in mouse embryonic fibroblasts

HIGHLIGHTS

  • who: Maximilian N. Kinzler from the InstitutUniversity Frankfurt have published the research: STF-62247 and pimozide induce autophagy and autophagic cell death in mouse embryonic fibroblasts, in the Journal: Scientific Reports Scientific Reports
  • what: The authors explored the efficacy of STF-62247 and pimozide as autophagy-inducing compounds and how these compounds engage lethal autophagy in mouse embryonic fibroblasts (MEFs) as a model system of autophagy. For further experiments, the authors intended to select a drug concentration that would lead to substantial cell killing while at the same time inducing an autophagy-dependent cell death . . .

     

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