HIGHLIGHTS
- who: Moaz Ahmad and collaborators from the Health, Bethesda, MD, USA have published the research: STIM Proteins and Regulation of SOCE in ER-PM Junctions, in the Journal: Biomolecules 2022, 12, 1152. of /2022/
- what: This study showed that endogenous STIM2 is pre-clustered in the ER-PM junctional region of cells under basal conditions.
- future: Although more research is needed to determine whether STIM2 is essential for SOCE-dependent AC8 activation it can be speculated that Orai1 targeting by STIM2 to the AKAP79 complex may also contribute to Ca2+ -dependent fast inactivation . . .
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