Stoichiometry of base excision repair proteins correlates with increased somatic cag instability in striatum over cerebellum in huntington’s disease transgenic mice

HIGHLIGHTS

• who: Agathi-Vassiliki Goula and colleagues from the Editor: Christopher EPearson, The Hospital for Sick Children and University of Toronto, Canada have published the Article: Stoichiometry of Base Excision Repair Proteins Correlates with Increased Somatic CAG Instability in Striatum over Cerebellum in Huntington’s Disease Transgenic Mice, in the Journal: (JOURNAL) of May/19,/2009
• what: The authors show that in HD mice oxidative DNA damage abnormally accumulates at CAG repeats in a length-dependent but age- and tissue-independent manner indicating that oxidative DNA damage alone is not sufficient to trigger somatic instability. The . . .
  

   

  

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