Straightforward access to a new class of dual dyrk1a/clk1 inhibitors possessing a simple dihydroquinoline core

HIGHLIGHTS

• who: Mihaela-Liliana u0162u00eenu0163au015f and colleagues from the UnivRouen, CNRS UMR , COBRA, FR, France have published the research: Straightforward Access to a New Class of Dual DYRK1A/CLK1 Inhibitors Possessing a Simple Dihydroquinoline Core, in the Journal: Molecules 2023, 36 of /2023/
• what: Based on previously described in the literature (namely TG003 and INDY) the authors report in this work new class of dihydroquinolines exhibiting inhibitory activities in the nanomolar range on hDYRK1A and hCLK1.
• future: Gratifyingly N-propyl dihydroquinoline 1p turned out to be 2.5-fold more analysis weN-methyl sought . . .
  

   

  

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