HIGHLIGHTS
- who: Micaela Finney from the (UNIVERSITY) have published the research work: Strategies to improve homology-based repair outcomes following CRISPR-based gene editing in mosquitoes: lessons in how to keep any repair disruptions local, in the Journal: (JOURNAL)
- what: In this review, the authors examine recent strategies and breakthroughs in vertebrate systems related to the development of methods to bias DNA repair outcomes only at the DSB of interest, while leaving global repair alone. The authors discuss how these efforts to make the local DSB of interest more favorable for HDR with modified nuclease systems . . .
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