Streptococcus pneumoniae pneumolysin and neuraminidase a convert high-density lipoproteins into pro-atherogenic particles

HIGHLIGHTS

• who: Shahan Syed from the of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland have published the paper: Streptococcus pneumoniae pneumolysin and neuraminidase A convert high-density lipoproteins into pro-atherogenic particles, in the Journal: (JOURNAL) of June/25,/2021
• what: The authors show here that S. pneumoniae PLY and NanA interact with HDL. The authors demonstrate that sialic acids have a role in protecting HDL from PLY and possibly also from complement as NanA reduced HDL complement resistance.
• how: As HDL is capable of neutralizing the endotoxicity of LPS similarly the authors . . .
  

   

  

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