Stress responses in down syndrome neurodegeneration: state of the art and therapeutic molecules

HIGHLIGHTS

• who: Chiara Lanzillotta and Fabio Di Domenico from the Department of Biochemical Sciences "ARossi Fanelli", Laboratory Affiliated to Istituto Pasteur Italia-Fondazione have published the paper: Stress Responses in Down Syndrome Neurodegeneration: State of the Art and Therapeutic Molecules, in the Journal: Biomolecules 2021, 266 of /2021/
• what: The overall objective of this review is to examine the state of the art of stress response pathways in DS, a peculiar member of the family of NDDs. This study proposed that chronic PERK activation was an early and toxic mechanism in DS, which precedes tau and . . .
  

   

  

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