HIGHLIGHTS
SUMMARY
Striatal dopamine boosts stimulus specificity in the visual cortex To investigate the hypothesis that striatal dopamine gates currently relevant cortical representations, the authors assessed how methylphenidate, sulpiride, and striatal dopamine synthesis capacity affected activity in the task-relevant stimulus-specific visual association cortices. The authors reasoned that if striatal dopamine gates the activity in these regions in proportion to outcome surprise, then the dopaminergic drugs should affect this stimulus-specific reversal signal in visual cortex in a striatal dopamine synthesis-dependent manner. Both methylphenidate and sulpiride increased stimulus-specific_activity during unexpected outcomes to a . . .
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