Stroke genetics informs drug discovery and risk prediction across ancestries

HIGHLIGHTS

• who: Aniket Mishra from the (UNIVERSITY) have published the article: Stroke genetics informs drug discovery and risk prediction across ancestries, in the Journal: (JOURNAL) of 15/Dec/2021
• what: Using a three-pronged approach4, the authors provide genetic evidence for putative drug effects, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as possible targets, with drugs already under investigation for stroke for F11 and PROC.
• how: To detect putative causal regulatory variants the authors conducted an in silico mutagenesis analysis using MENTR a machine-learning method to precisely predict transcriptional changes caused by . . .
  

   

  

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