HIGHLIGHTS
- who: Wenjie Zheng from the Yokohama City University, Japan have published the paper: Strong inflammatory signatures in the neutrophils of PAMI syndrome, in the Journal: (JOURNAL)
- what: The inflammatory signatures in neutrophils revealed in the patient with PAMI in the study provided insights for better understanding of the disease mechanisms.
SUMMARY
As a consequence, pyrin inflammasome was assembled to activate caspase-1 and process proinflammatory cytokines pro-interleukin-1b (IL-1b) and pro-IL-18 into mature IL-1b and IL-18. Although serum IL-18 elevation has been previously reported . . .
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