Structural analyses of nudt16-adp-ribose complexes direct rational design of mutants with improved processing of poly(adp-ribosyl)ated proteins

HIGHLIGHTS

• who: Puchong Thirawatananond from the Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, USA Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. have published the research work: Structural analyses of NudT16-ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins, in the Journal: Scientific Reports Scientific Reports of 12/Dec/2018
• what: The authors report the crystal_structures of HsNudT16 in complex with ADPr and dimeric ADPr (di-ADPr).
• how: The authors identified several mutants (Δ17 F36A . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or E-mail:

  If you don't have an account, you can create one here.