Structural and biochemical basis of etoposide-resistant mutations in topoisomerase ii

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  • who: Elizabeth G. Gibson and Joseph E. Deweese from the Department of Pharmaceutical Sciences, Lipscomb University College of Pharmacy, Bristol Myers Squibb, Princeton, NJ, USA have published the research work: Structural and Biochemical Basis of Etoposide-Resistant Mutations in Topoisomerase II, in the Journal: Symmetry 2022, 1309 of 24/06/2022
  • what: In some cases the authors report the first data on purified versions of these enzymes. The Here, the authors report the purification and of point mutants with altered mutations the authors selected are based on the studies mentioned above including the following sensitivity . . .

     

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