Structural and biochemical characterization of an active arylamine n-acetyltransferase possessing a non-canonical cys-his-glu catalytic triad*

HIGHLIGHTS

• who: Xavier Kubiak from the (UNIVERSITY) have published the Article: Structural and Biochemical Characterization of an Active Arylamine N-Acetyltransferase Possessing a Non-canonical Cys-His-Glu Catalytic Triad*, in the Journal: (JOURNAL) of March/11,/2013
• what: For the first time, the authors demonstrate the existence of a non-canonical but functional Cys-HisGlu catalytic triad in an NAT. Considering the similar chemistry of the Asp and Glu residues and the results of the kinetic study of_(BACCR)NAT3 enzymes, the authors propose that the accommodation of a Glu as a catalytic residue in . . .
  

   

  

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