Structural and dynamic disturbances revealed by molecular dynamics simulations predict the impact on function of cct5 chaperonin mutations associated with rare severe distal neuropathies

HIGHLIGHTS

• who: Federica Scalia and colleagues from the Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), University of Palermo, Palermo, Italy have published the article: Structural and Dynamic Disturbances Revealed by Molecular Dynamics Simulations Predict the Impact on Function of CCT5 Chaperonin Mutations Associated with Rare Severe Distal Neuropathies, in the Journal: (JOURNAL) of 27/Dec/2022
• what: The authors report the structural and dynamic disturbances revealed by molecular dynamics simulations associated with the Leu224Val and His147Arg mutants. The models show a marked conformational change of the apical domain in both variants, particularly under ATP-bound . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or E-mail:

  If you don't have an account, you can create one here.